Neurological Manifestations in a Cohort of Egyptian Patients With COVID-19: A Prospective, Multicenter, Observational Study

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aut.relation.articlenumber74en_NZ
aut.relation.issue1en_NZ
aut.relation.journalBrain Sciencesen_NZ
aut.relation.volume12en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorMekkawy, DAen_NZ
dc.contributor.authorHamdy, Sen_NZ
dc.contributor.authorAbdel-Naseer, Men_NZ
dc.contributor.authorShehata, HSen_NZ
dc.contributor.authorHalfawy, AAen_NZ
dc.contributor.authorShalaby, NMen_NZ
dc.contributor.authorShehata, GAen_NZ
dc.contributor.authorAli, AMen_NZ
dc.contributor.authorElmazny, Aen_NZ
dc.contributor.authorAhmed, SMen_NZ
dc.contributor.authorIsmail, JHen_NZ
dc.contributor.authorIbraheim, Aen_NZ
dc.contributor.authorAbdel-Hamid, HMen_NZ
dc.contributor.authorMagdy, Ren_NZ
dc.contributor.authorKabara Ayoub, Yen_NZ
dc.contributor.authorTaha, AEen_NZ
dc.contributor.authorMerghany, Nen_NZ
dc.contributor.authorSoliman, NMen_NZ
dc.contributor.authorElshebawy, Hen_NZ
dc.contributor.authorAbdelal, SESen_NZ
dc.contributor.authorEl-Ghoneimy, Len_NZ
dc.contributor.authorAl-Athwari, Aen_NZ
dc.contributor.authorKishk, NAen_NZ
dc.contributor.authorNada, MAFen_NZ
dc.contributor.authorFarghaly, Men_NZ
dc.contributor.authorHassan, Aen_NZ
dc.contributor.authorHegazy, MIen_NZ
dc.contributor.authorAbdelalim, Aen_NZ
dc.contributor.authorMourad, HSen_NZ
dc.contributor.authorHassouna, Aen_NZ
dc.contributor.authorOthman, ASen_NZ
dc.contributor.authorWijeratne, Ten_NZ
dc.date.accessioned2022-05-30T00:03:27Z
dc.date.available2022-05-30T00:03:27Z
dc.date.copyright2022en_NZ
dc.date.issued2022en_NZ
dc.description.abstractBackground: The COVID-19 pandemic has reached over 276 million people globally with 5.3 million deaths as of 22nd December 2021. COVID-19-associated acute and long-term neurological manifestations are well recognized. The exact profile and the timing of neurological events in relation to the onset of infection are worth exploring. The aim of the current body of work was to determine the frequency, pattern, and temporal profile of neurological manifestations in a cohort of Egyptian patients with confirmed COVID-19 infection. Methods: This was a prospective study conducted on 582 hospitalized COVID-19 patients within the first two weeks of the diagnosis of COVID-19 to detect any specific or non-specific neurological events. Results: The patients’ mean (SD) age was 46.74 (17.26) years, and 340 (58.42%) patients were females. The most commonly encountered COVID-19 symptoms were fever (90.72%), cough (82.99%), and fatigue (76.98%). Neurological events (NE) detected in 283 patients (48.63%) and were significantly associated with a severe COVID-19 at the onset (OR: 3.13; 95% CI: 2.18–4.51; p < 0.0001) and with a higher mortality (OR: 2.56; 95% CI: 1.48–5.46; p = 0.019). The most frequently reported NEs were headaches (n = 167) and myalgias (n = 126). Neurological syndromes included stroke (n = 14), encephalitis (n = 12), encephalopathy (n = 11), transverse myelitis (n = 6) and Guillain-Barré syndrome (n = 4). Conclusions: Neurological involvement is common (48.63%) in COVID-19 patients within the first two weeks of the illness. This includes neurological symptoms such as anosmia, headaches, as well as a constellation of neurological syndromes such as stroke, encephalitis, transverse myelitis, and Guillain-Barré syndrome. Severity of acute COVID-19 illness and older age are the main risk factors.en_NZ
dc.identifier.citationBrain Sciences, 12(1), 74. https://doi.org/10.3390/brainsci12010074
dc.identifier.doi10.3390/brainsci12010074en_NZ
dc.identifier.issn2076-3425en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15175
dc.languageenen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/2076-3425/12/1/74
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectCOVID-19; Neurological disorders; Serial systemic immune inflammatory indices (SSIIi); Stroke
dc.titleNeurological Manifestations in a Cohort of Egyptian Patients With COVID-19: A Prospective, Multicenter, Observational Studyen_NZ
dc.typeJournal Article
pubs.elements-id454930
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Public Health & Interdisciplinary Studies/Biosciences Department
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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