Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?

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aut.relation.articlenumber108en_NZ
aut.relation.issue5en_NZ
aut.relation.journalBiomedicinesen_NZ
aut.relation.volume8en_NZ
dark.contributor.authorGuildford, Len_NZ
dark.contributor.authorCrofts, Cen_NZ
dark.contributor.authorLu, Jen_NZ
dc.date.accessioned2020-06-28T22:08:17Z
dc.date.available2020-06-28T22:08:17Z
dc.date.copyright2020en_NZ
dc.date.issued2020en_NZ
dc.description.abstractHyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2-5minutes). It is theorised that c-peptide levels (half-life 20-30minutes) would be a better proxy for insulin due to both hormones being released in equimolar amounts. However, the correlation between c-peptide and insulin levels is unknown. We aim to identify their correlation following a four-hour oral glucose tolerance test (OGTT). Data were obtained from records of routine medical care at St Joseph's Hospital, Chicago, IL, USA, during 1977. Two hundred and fifty-five male and female participants aged over 20 years undertook a fourhour OGTT with plasma glucose, insulin and c-peptide levels recorded. Correlation was assessed with Pearson's correlation. There was a weak correlation between insulin and c-peptide, which increased to moderate across the four-hour OGTT (r = 0.482-0.680). There was no significant change in this relationship when data was subdivided according to either the WHO glucose status or Kraft insulin response. Although there was a correlation between insulin and c-peptide, it was too weak to recommend the use of c-peptide as an alternative biomarker for the diagnosis of hyperinsulinaemia.en_NZ
dc.identifier.citationBiomedicines, 8(5), 108. doi:10.3390/biomedicines8050108
dc.identifier.doi10.3390/biomedicines8050108en_NZ
dc.identifier.issn2227-9059en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13456
dc.languageengen_NZ
dc.publisherMDPI
dc.relation.urihttps://www.mdpi.com/2227-9059/8/5/108
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectC-Peptideen_NZ
dc.subjectCorrelationen_NZ
dc.subjectHyperinsulinaemiaen_NZ
dc.subjectInsulinen_NZ
dc.subjectOral glucose tolerance testen_NZ
dc.subjectPredictionen_NZ
dc.titleCan the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?en_NZ
dc.typeJournal Article
pubs.elements-id374961
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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