Population-level Risks of Alcohol Consumption by Amount, Geography, Age, Sex, and Year: A Systematic Analysis for the Global Burden of Disease Study 2020

aut.relation.endpage235
aut.relation.issue10347en_NZ
aut.relation.journalThe Lanceten_NZ
aut.relation.startpage185
aut.relation.volume400en_NZ
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dc.contributor.authorSchwarzinger, Men_NZ
dc.contributor.authorSchwebel, DCen_NZ
dc.contributor.authorSeidu, A-Aen_NZ
dc.contributor.authorSenthil Kumar, Nen_NZ
dc.contributor.authorSeyedAlinaghi, Sen_NZ
dc.contributor.authorSeylani, Aen_NZ
dc.contributor.authorSha, Fen_NZ
dc.contributor.authorShahin, Sen_NZ
dc.contributor.authorShahraki-Sanavi, Fen_NZ
dc.contributor.authorShahrokhi, Sen_NZ
dc.contributor.authorShaikh, MAen_NZ
dc.contributor.authorShaker, Een_NZ
dc.contributor.authorShakhmardanov, MZen_NZ
dc.contributor.authorShams-Beyranvand, Men_NZ
dc.contributor.authorSheikhbahaei, Sen_NZ
dc.contributor.authorSheikhi, RAen_NZ
dc.contributor.authorShetty, Aen_NZ
dc.contributor.authorShetty, JKen_NZ
dc.contributor.authorShiferaw, DSen_NZ
dc.contributor.authorShigematsu, Men_NZ
dc.contributor.authorShiri, Ren_NZ
dc.contributor.authorShirkoohi, Ren_NZ
dc.contributor.authorShivakumar, KMen_NZ
dc.contributor.authorShivarov, Ven_NZ
dc.contributor.authorShobeiri, Pen_NZ
dc.contributor.authorShrestha, Ren_NZ
dc.contributor.authorSidemo, NBen_NZ
dc.contributor.authorSigfusdottir, IDen_NZ
dc.contributor.authorSilva, DASen_NZ
dc.contributor.authorSilva, NTDen_NZ
dc.contributor.authorSingh, JAen_NZ
dc.contributor.authorSingh, Sen_NZ
dc.contributor.authorSkryabin, VYen_NZ
dc.contributor.authorSkryabina, AAen_NZ
dc.contributor.authorSleet, DAen_NZ
dc.contributor.authorSolmi, Men_NZ
dc.contributor.authorSOLOMON, Yen_NZ
dc.contributor.authorSong, Sen_NZ
dc.contributor.authorSong, Yen_NZ
dc.contributor.authorSorensen, RJDen_NZ
dc.contributor.authorSoshnikov, Sen_NZ
dc.contributor.authorSoyiri, INen_NZ
dc.contributor.authorStein, DJen_NZ
dc.contributor.authorSubba, SHen_NZ
dc.contributor.authorSzócska, Men_NZ
dc.contributor.authorTabarés-Seisdedos, Ren_NZ
dc.contributor.authorTabuchi, Ten_NZ
dc.contributor.authorTaheri, Men_NZ
dc.contributor.authorTan, K-Ken_NZ
dc.contributor.authorTareke, Men_NZ
dc.contributor.authorTarkang, EEen_NZ
dc.contributor.authorTemesgen, Gen_NZ
dc.contributor.authorTemesgen, WAen_NZ
dc.contributor.authorTemsah, M-Hen_NZ
dc.contributor.authorThankappan, KRen_NZ
dc.contributor.authorThapar, Ren_NZ
dc.contributor.authorThomas, NKen_NZ
dc.contributor.authorTiruneh, Cen_NZ
dc.contributor.authorTodorovic, Jen_NZ
dc.contributor.authorTorrado, Men_NZ
dc.contributor.authorTouvier, Men_NZ
dc.contributor.authorTovani-Palone, MRen_NZ
dc.contributor.authorTran, MTNen_NZ
dc.contributor.authorTrias-Llimós, Sen_NZ
dc.contributor.authorTripathy, JPen_NZ
dc.contributor.authorVakilian, Aen_NZ
dc.contributor.authorValizadeh, Ren_NZ
dc.contributor.authorVarmaghani, Men_NZ
dc.contributor.authorVarthya, SBen_NZ
dc.contributor.authorVasankari, TJen_NZ
dc.contributor.authorVos, Ten_NZ
dc.contributor.authorWagaye, Ben_NZ
dc.contributor.authorWaheed, Yen_NZ
dc.contributor.authorWalde, MTen_NZ
dc.contributor.authorWang, Cen_NZ
dc.contributor.authorWang, Yen_NZ
dc.contributor.authorWang, Y-Pen_NZ
dc.contributor.authorWesterman, Ren_NZ
dc.contributor.authorWickramasinghe, NDen_NZ
dc.contributor.authorWubetu, ADen_NZ
dc.contributor.authorXu, Sen_NZ
dc.contributor.authorYamagishi, Ken_NZ
dc.contributor.authorYang, Len_NZ
dc.contributor.authorYesera, GEEen_NZ
dc.contributor.authorYigit, Aen_NZ
dc.contributor.authorYiğit, Ven_NZ
dc.contributor.authorYimaw, AEAEen_NZ
dc.contributor.authorYon, DKen_NZ
dc.contributor.authorYonemoto, Nen_NZ
dc.contributor.authorYu, Cen_NZ
dc.contributor.authorZadey, Sen_NZ
dc.contributor.authorZahir, Men_NZ
dc.contributor.authorZare, Ien_NZ
dc.contributor.authorZastrozhin, MSen_NZ
dc.contributor.authorZastrozhina, Aen_NZ
dc.contributor.authorZhang, Z-Jen_NZ
dc.contributor.authorZhong, Cen_NZ
dc.contributor.authorZmaili, Men_NZ
dc.contributor.authorZuniga, YMHen_NZ
dc.contributor.authorGakidou, Een_NZ
dc.date.accessioned2022-08-08T23:17:06Z
dc.date.available2022-08-08T23:17:06Z
dc.date.copyright2022-07en_NZ
dc.date.issued2022-07en_NZ
dc.description.abstractBackground The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods For this analysis, we constructed burden-weighted dose–response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15–95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol. Findings The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15–39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0–0) and 0·603 (0·400–1·00) standard drinks per day, and the NDE varied between 0·002 (0–0) and 1·75 (0·698–4·30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0·114 (0–0·403) to 1·87 (0·500–3·30) standard drinks per day and an NDE that ranged between 0·193 (0–0·900) and 6·94 (3·40–8·30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59·1% (54·3–65·4) were aged 15–39 years and 76·9% (73·0–81·3) were male. Interpretation There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol.
dc.identifier.citationThe Lancet, Volume 400, Issue 10347, 16–22 July 2022, pp. 185-235.
dc.identifier.doi10.1016/s0140-6736(22)00847-9en_NZ
dc.identifier.issn0140-6736en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/15351
dc.languageenen_NZ
dc.publisherElsevier BVen_NZ
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0140673622008479
dc.rights© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
dc.rights.accessrightsOpenAccessen_NZ
dc.titlePopulation-level Risks of Alcohol Consumption by Amount, Geography, Age, Sex, and Year: A Systematic Analysis for the Global Burden of Disease Study 2020en_NZ
dc.typeJournal Article
pubs.elements-id459402
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Faculty of Health & Environmental Science
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/National Institute Stroke & Applied Neurosciences
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/National Institute Stroke & Applied Neurosciences/NISAN - Stroke
pubs.organisational-data/AUT/Faculty of Health & Environmental Science/School of Clinical Sciences
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HY Public Health & Psychosocial Studies 2018 PBRF
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