The Effects of Chiropractic Spinal Adjustment on EEG in Adults with Alzheimer's and Parkinson's Disease: A Pilot Randomised Cross-over Trial

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aut.relation.issue5
aut.relation.journalJournal of Integrative Neuroscience
aut.relation.startpage98
aut.relation.volume23
dc.contributor.authorNavid, MS
dc.contributor.authorNiazi, IK
dc.contributor.authorHolt, K
dc.contributor.authorNedergaard, RB
dc.contributor.authorAmjad, I
dc.contributor.authorGhani, U
dc.contributor.authorKumari, N
dc.contributor.authorShafique, M
dc.contributor.authorDuehr, J
dc.contributor.authorTrager, RJ
dc.contributor.authorHaavik, H
dc.date.accessioned2024-08-09T02:48:07Z
dc.date.available2024-08-09T02:48:07Z
dc.date.issued2024-01-01
dc.description.abstractObjectives: In this study, we explored the effects of chiropractic spinal adjustments on resting-state electroencephalography (EEG) recordings and early somatosensory evoked potentials (SEPs) in Alzheimer’s and Parkinson’s disease. Methods: In this randomized cross-over study, 14 adults with Alzheimer’s disease (average age 67 ± 6 years, 2 females:12 males) and 14 adults with Parkinson’s disease (average age 62 ± 11 years, 1 female:13 males) participated. The participants underwent chiropractic spinal adjustments and a control (sham) intervention in a randomized order, with a minimum of one week between each intervention. EEG was recorded before and after each intervention, both during rest and stimulation of the right median nerve. The power-spectra was calculated for resting-state EEG, and the amplitude of the N30 peak was assessed for the SEPs. The source localization was performed on the power-spectra of resting-state EEG and the N30 SEP peak. Results: Chiropractic spinal adjustment significantly reduced the N30 peak in individuals with Alzheimer’s by 15% (p = 0.027). While other outcomes did not reach significance, resting-state EEG showed an increase in absolute power in all frequency bands after chiropractic spinal adjustments in individuals with Alzheimer’s and Parkinson’s disease. The findings revealed a notable enhancement in connectivity within the Default Mode Network (DMN) at the alpha, beta, and theta frequency bands among individuals undergoing chiropractic adjustments. Conclusions: We found that it is feasible to record EEG/SEP in individuals with Alzheimer’s and Parkinson’s disease. Additionally, a single session of chiropractic spinal adjustment reduced the somatosensory evoked N30 potential and enhancement in connectivity within the DMN at the alpha, beta, and theta frequency bands in individuals with Alzheimer’s disease. Future studies may require a larger sample size to estimate the effects of chiropractic spinal adjustment on brain activity. Given the preliminary nature of our findings, caution is warranted when considering the clinical implications.
dc.identifier.citationJournal of Integrative Neuroscience, ISSN: 0219-6352 (Print); 1757-448X (Online), IMR Press, 23(5), 98-. doi: 10.31083/j.jin2305098
dc.identifier.doi10.31083/j.jin2305098
dc.identifier.issn0219-6352
dc.identifier.issn1757-448X
dc.identifier.urihttp://hdl.handle.net/10292/17858
dc.languageeng
dc.publisherIMR Press
dc.relation.urihttps://www.imrpress.com/journal/JIN/23/5/10.31083/j.jin2305098
dc.rightsCopyright: © 2024 The Author(s). Published by IMR Press. This is an open access article under the CC BY 4.0 license.
dc.rights.accessrightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer disease
dc.subjectParkinson disease
dc.subjectbrain waves
dc.subjectchiropractic
dc.subjectelectroencephalography
dc.subjectsomatosensory evoked potentials
dc.subjectspinal adjustment
dc.subject5202 Biological Psychology
dc.subject32 Biomedical and Clinical Sciences
dc.subject3209 Neurosciences
dc.subject52 Psychology
dc.subjectClinical Research
dc.subjectAlzheimer's Disease
dc.subjectAging
dc.subjectNeurosciences
dc.subjectAcquired Cognitive Impairment
dc.subjectDementia
dc.subjectNeurodegenerative
dc.subjectAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
dc.subjectParkinson's Disease
dc.subjectClinical Trials and Supportive Activities
dc.subjectBrain Disorders
dc.subjectNeurological
dc.subject09 Engineering
dc.subject11 Medical and Health Sciences
dc.subject17 Psychology and Cognitive Sciences
dc.subjectNeurology & Neurosurgery
dc.subject3209 Neurosciences
dc.subject5202 Biological psychology
dc.subject.meshHumans
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshParkinson Disease
dc.subject.meshAged
dc.subject.meshCross-Over Studies
dc.subject.meshAlzheimer Disease
dc.subject.meshElectroencephalography
dc.subject.meshMiddle Aged
dc.subject.meshEvoked Potentials, Somatosensory
dc.subject.meshPilot Projects
dc.subject.meshManipulation, Chiropractic
dc.subject.meshHumans
dc.subject.meshParkinson Disease
dc.subject.meshAlzheimer Disease
dc.subject.meshElectroencephalography
dc.subject.meshManipulation, Chiropractic
dc.subject.meshPilot Projects
dc.subject.meshCross-Over Studies
dc.subject.meshEvoked Potentials, Somatosensory
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshParkinson Disease
dc.subject.meshAged
dc.subject.meshCross-Over Studies
dc.subject.meshAlzheimer Disease
dc.subject.meshElectroencephalography
dc.subject.meshMiddle Aged
dc.subject.meshEvoked Potentials, Somatosensory
dc.subject.meshPilot Projects
dc.subject.meshManipulation, Chiropractic
dc.titleThe Effects of Chiropractic Spinal Adjustment on EEG in Adults with Alzheimer's and Parkinson's Disease: A Pilot Randomised Cross-over Trial
dc.typeJournal Article
pubs.elements-id556087
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