Carbon-carbon Double Bond and Resorcinol in Resveratrol and Its Analogues: What Is the Characteristic Structure in Quenching Singlet Oxygen?

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aut.relation.articlenumber268en_NZ
aut.relation.issue7en_NZ
aut.relation.journalBiomoleculesen_NZ
aut.relation.volume9en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorKong, Qen_NZ
dc.contributor.authorRen, Xen_NZ
dc.contributor.authorQi, Jen_NZ
dc.contributor.authorYu, Jen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorWang, Sen_NZ
dc.date.accessioned2020-06-28T22:58:39Z
dc.date.available2020-06-28T22:58:39Z
dc.date.copyright2019en_NZ
dc.date.issued2019en_NZ
dc.description.abstractStilbenes, particularly resveratrol and resveratrol dimers, could effectively quench singlet oxygen (1O2). It was reported that both resorcinol and carbon-carbon double bond quenching 1O2 can participate in the mechanism. However, it is still not clear which structure plays a dominant role in quenching 1O2. To investigate the characteristic structure in the mechanism of quenching 1O2, the resveratrol, pterostilbene and piceatannol quenching 1O2 abilities were compared by UHPLC-QTOF-MS2 and UHPLC-QQQ-MS2. Results showed that catechol, carbon-carbon double bond and resorcinol participated in the quenching of 1O2. Catechol ring plays a leading role in the mechanism, and the contribution of the structures in quenching 1O2 activity are as follows: catechol ring > carbon-carbon double bond > resorcinol ring, which is supported by the calculation of energy. Our findings will contribute to the future screening of stilbenes with higher activity, and those stilbenes may have great therapeutic potential in 1O2-mediated diseases.en_NZ
dc.identifier.citationBiomolecules 2019, 9(7), 268; https://doi.org/10.3390/biom9070268
dc.identifier.doi10.3390/biom9070268en_NZ
dc.identifier.issn2218-273Xen_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13459
dc.languageengen_NZ
dc.publisherMDPI AGen_NZ
dc.relation.urihttps://www.mdpi.com/2218-273X/9/7/268
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectResveratrol analoguesen_NZ
dc.subjectUHPLC-QQQ-MS2en_NZ
dc.subjectUHPLC-QTOF-MS2en_NZ
dc.subjectHydroxyl groupsen_NZ
dc.subjectResorcinolen_NZ
dc.subjectSinglet-oxygen quencheren_NZ
dc.titleCarbon-carbon Double Bond and Resorcinol in Resveratrol and Its Analogues: What Is the Characteristic Structure in Quenching Singlet Oxygen?en_NZ
dc.typeJournal Article
pubs.elements-id362143
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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