Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-glucosidase More Strongly Than α-amylase and Amyloglucosidase

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aut.relation.articlenumber831en_NZ
aut.relation.journalFrontiers in Pharmacologyen_NZ
aut.relation.volume11en_NZ
aut.researcherDrabsch, Julie
dc.contributor.authorKoh, HSAen_NZ
dc.contributor.authorLu, Jen_NZ
dc.contributor.authorZhou, Wen_NZ
dc.date.accessioned2020-07-27T02:27:59Z
dc.date.available2020-07-27T02:27:59Z
dc.date.copyright2020en_NZ
dc.date.issued2020en_NZ
dc.description.abstractFucoidan refers to a group of sulfated polysaccharide that is commonly obtained from various species of brown seaweed. Fucoidan has gained increased popularity among researchers in the recent years due to its numerous biological activities, including its inhibitory effects against starch hydrolyzing enzymes such as α-amylase and α-glucosidase. This highlights the potential of fucoidan as an antidiabetic agent in the management and prevention of diabetes mellitus. In this study, the inhibitory effects of fucoidan isolated from the New Zealand Undaria pinnatifida seaweed species against three starch hydrolyzing enzymes-α-amylase, α-glucosidase, and amyloglucosidase-was investigated. It was demonstrated that while the fucoidan exhibited significant inhibitory effects against all the three starch hydrolases, it is an uncompetitive inhibitor of α-amylase and amyloglucosidase, and is a competitive inhibitor of α-glucosidase. Moreover, it exhibited significantly stronger inhibitory effects against α-glucosidase than α-amylase, thus having the desirable characteristics as an antidiabetic agent.en_NZ
dc.identifier.citationFrontiers in Pharmacology, 11, 831.
dc.identifier.doi10.3389/fphar.2020.00831en_NZ
dc.identifier.issn1663-9812en_NZ
dc.identifier.urihttps://hdl.handle.net/10292/13554
dc.languageengen_NZ
dc.publisherFrontiers Mediaen_NZ
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fphar.2020.00831/full
dc.rightsCopyright © 2020 Koh, Lu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.accessrightsOpenAccessen_NZ
dc.subjectDiabetesen_NZ
dc.subjectUndaria pinnatifidaen_NZ
dc.subjectAmyloglucosidaseen_NZ
dc.subjectFucoidanen_NZ
dc.subjectα-amylaseen_NZ
dc.subjectα-glucosidaseen_NZ
dc.titleStructural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-glucosidase More Strongly Than α-amylase and Amyloglucosidaseen_NZ
dc.typeJournal Article
pubs.elements-id380001
pubs.organisational-data/AUT
pubs.organisational-data/AUT/Health & Environmental Science
pubs.organisational-data/AUT/Health & Environmental Science/Interprofessional Health
pubs.organisational-data/AUT/PBRF
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences
pubs.organisational-data/AUT/PBRF/PBRF Health and Environmental Sciences/HI Interprofessional 2018 PBRF
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