Frequency and Predictors of Headache in the First 12 Months After Traumatic Brain Injury: Results from CENTER-TBI

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aut.relation.articlenumber44
aut.relation.issue1
aut.relation.journalThe Journal of Headache and Pain
aut.relation.startpage44
aut.relation.volume25
dc.contributor.authorHowe, Emilie Isager
dc.contributor.authorAndelic, Nada
dc.contributor.authorBrunborg, Cathrine
dc.contributor.authorZeldovich, Marina
dc.contributor.authorHelseth, Eirik
dc.contributor.authorSkandsen, Toril
dc.contributor.authorOlsen, Alexander
dc.contributor.authorFure, Silje CR
dc.contributor.authorTheadom, Alice
dc.contributor.authorRauen, Katrin
dc.contributor.authorMadsen, Benedikte Å
dc.contributor.authorJacobs, Bram
dc.contributor.authorvan der Naalt, Joukje
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorEinarsen, Cathrine Elisabeth
dc.contributor.authorStorvig, Gøril
dc.contributor.authorTronvik, Erling
dc.contributor.authorTverdal, Cathrine
dc.contributor.authorvon Steinbüchel, Nicole
dc.contributor.authorRøe, Cecilie
dc.contributor.authorHellstrøm, Torgeir
dc.contributor.authorCENTER-TBI Participants and Investigators
dc.date.accessioned2024-04-03T04:28:08Z
dc.date.available2024-04-03T04:28:08Z
dc.date.issued2024-03-25
dc.description.abstractBACKGROUND: Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. METHODS: A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. RESULTS: A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. CONCLUSIONS: Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. TRIAL REGISTRATION: ClinicalTrials.gov NCT02210221.
dc.identifier.citationThe Journal of Headache and Pain, ISSN: 1129-2369 (Print); 1129-2377 (Online), BMC, 25(1), 44-. doi: 10.1186/s10194-024-01751-0
dc.identifier.doi10.1186/s10194-024-01751-0
dc.identifier.issn1129-2369
dc.identifier.issn1129-2377
dc.identifier.urihttp://hdl.handle.net/10292/17402
dc.languageeng
dc.publisherBMC
dc.relation.urihttps://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-024-01751-0
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBrain trauma
dc.subjectObservational study
dc.subjectPost-traumatic headache
dc.subjectSecondary headache disorders
dc.subjectBrain trauma
dc.subjectObservational study
dc.subjectPost-traumatic headache
dc.subjectSecondary headache disorders
dc.subjectCENTER-TBI Participants and Investigators
dc.subject32 Biomedical and Clinical Sciences
dc.subject3202 Clinical Sciences
dc.subjectNeurosciences
dc.subjectClinical Research
dc.subjectBrain Disorders
dc.subjectPain Research
dc.subjectHeadaches
dc.subjectTraumatic Head and Spine Injury
dc.subjectTraumatic Brain Injury (TBI)
dc.subjectChronic Pain
dc.subjectPhysical Injury - Accidents and Adverse Effects
dc.subjectInjuries and accidents
dc.subjectNeurological
dc.subject0604 Genetics
dc.subject1103 Clinical Sciences
dc.subjectNeurology & Neurosurgery
dc.subject3202 Clinical sciences
dc.subject3209 Neurosciences
dc.subject.meshAged
dc.subject.meshBrain Injuries, Traumatic
dc.subject.meshComorbidity
dc.subject.meshEmergency Service, Hospital
dc.subject.meshFemale
dc.subject.meshHeadache
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshProspective Studies
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshFemale
dc.subject.meshAged
dc.subject.meshProspective Studies
dc.subject.meshBrain Injuries, Traumatic
dc.subject.meshHeadache
dc.subject.meshComorbidity
dc.subject.meshEmergency Service, Hospital
dc.subject.meshHumans
dc.subject.meshHeadache
dc.subject.meshProspective Studies
dc.subject.meshComorbidity
dc.subject.meshAged
dc.subject.meshEmergency Service, Hospital
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshBrain Injuries, Traumatic
dc.titleFrequency and Predictors of Headache in the First 12 Months After Traumatic Brain Injury: Results from CENTER-TBI
dc.typeJournal Article
pubs.elements-id543482
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