A Randomized Controlled Trial Comparing Different Sites of High-Velocity Low Amplitude Thrust on Sensorimotor Integration Parameters

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aut.relation.articlenumber1159
aut.relation.issue1
aut.relation.journalScientific Reports
aut.relation.startpage1159
aut.relation.volume14
dc.contributor.authorNiazi, IK
dc.contributor.authorNavid, MS
dc.contributor.authorMerkle, C
dc.contributor.authorAmjad, I
dc.contributor.authorKumari, N
dc.contributor.authorTrager, RJ
dc.contributor.authorHolt, K
dc.contributor.authorHaavik, H
dc.date.accessioned2024-04-03T04:36:22Z
dc.date.available2024-04-03T04:36:22Z
dc.date.issued2024-01-12
dc.description.abstractIncreasing evidence suggests that a high-velocity, low-amplitude (HVLA) thrust directed at a dysfunctional vertebral segment in people with subclinical spinal pain alters various neurophysiological measures, including somatosensory evoked potentials (SEPs). We hypothesized that an HVLA thrust applied to a clinician chosen vertebral segment based on clinical indicators of vertebral dysfunction, in short, segment considered as “relevant” would significantly reduce the N30 amplitude compared to an HVLA thrust applied to a predetermined vertebral segment not based on clinical indicators of vertebral dysfunction or segment considered as “non-relevant”. In this double-blinded, active-controlled, parallel-design study, 96 adults with recurrent mild neck pain, ache, or stiffness were randomly allocated to receiving a single thrust directed at either a segment considered as “relevant” or a segment considered as “non-relevant" in their upper cervical spine. SEPs of median nerve stimulation were recorded before and immediately after a single HVLA application delivered using an adjusting instrument (Activator). A linear mixed model was used to assess changes in the N30 amplitude. A significant interaction between the site of thrust delivery and session was found (F1,840 = 9.89, p < 0.002). Pairwise comparisons showed a significant immediate decrease in the N30 complex amplitude after the application of HVLA thrust to a segment considered “relevant” (− 16.76 ± 28.32%, p = 0.005). In contrast, no significant change was observed in the group that received HVLA thrust over a segment considered “non-relevant” (p = 0.757). Cervical HVLA thrust applied to the segment considered as “relevant” altered sensorimotor parameters, while cervical HVLA thrust over the segment considered as “non-relevant” did not. This finding supports the hypothesis that spinal site targeting of HVLA interventions is important when measuring neurophysiological responses. Further studies are needed to explore the potential clinical relevance of these findings.
dc.identifier.citationScientific Reports, ISSN: 2045-2322 (Print); 2045-2322 (Online), Springer Science and Business Media LLC, 14(1), 1159-. doi: 10.1038/s41598-024-51201-9
dc.identifier.doi10.1038/s41598-024-51201-9
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10292/17406
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.urihttps://www.nature.com/articles/s41598-024-51201-9
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessrightsOpenAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject32 Biomedical and Clinical Sciences
dc.subject3202 Clinical Sciences
dc.subject42 Health Sciences
dc.subject4208 Traditional, Complementary and Integrative Medicine
dc.subjectChronic Pain
dc.subjectNeurosciences
dc.subjectPain Research
dc.subjectClinical Research
dc.subjectNeurodegenerative
dc.subjectClinical Trials and Supportive Activities
dc.subject.meshAdult
dc.subject.meshHumans
dc.subject.meshManipulation, Spinal
dc.subject.meshCervical Vertebrae
dc.subject.meshNeck
dc.subject.meshNeck Pain
dc.subject.meshNervous System Physiological Phenomena
dc.subject.meshNeck
dc.subject.meshCervical Vertebrae
dc.subject.meshHumans
dc.subject.meshNeck Pain
dc.subject.meshManipulation, Spinal
dc.subject.meshAdult
dc.subject.meshNervous System Physiological Phenomena
dc.subject.meshAdult
dc.subject.meshHumans
dc.subject.meshManipulation, Spinal
dc.subject.meshCervical Vertebrae
dc.subject.meshNeck
dc.subject.meshNeck Pain
dc.subject.meshNervous System Physiological Phenomena
dc.titleA Randomized Controlled Trial Comparing Different Sites of High-Velocity Low Amplitude Thrust on Sensorimotor Integration Parameters
dc.typeJournal Article
pubs.elements-id535753
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